A Biphasic drug delivery system is the new trend of treating diseases, where the drug needed to be released immediately as well as for long duration. Biphasic drug delivery comprise of 2 phases i.e. Immediate release phase and Sustained release phase. Few approaches had been explored in this drug delivery system like Bilayer tablets, Matrix tablets , Floating matrix tablets etc. But the drawbacks are always been a definite problems for tablets while incorporating two different phases in one tablet. To overcome these problem biphasic drug delivery through capsule device is prescribed drug delivery system. Various types of techniques employed for the development of this type of dosage form. Review focused on formulation aspect of biphasic drug delivery system and their evaluation techniques. The purpose of this comprehensive review is to compile the work going on this delivery system. Which provide the valuable information related to formulation aspect to achieve biphasic drug delivery and discussed the various factors affect and to overcome it. This article explains why the development and production of biphasic drug delivery system through capsule device needs to be carried out on purpose to overcome common bi-layer table and matrix tablets problems, such as layer-separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield, etc.
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